Posting Summary: The University of Virginia's Matrix Biology Lab, directed by Dr. Thomas Barker and Systems Genetics Lab, directed by Dr. Mete Civelek, seeks a Postdoctoral Research Associate to develop engineered therapeutic synthetic gene networks based on fibroblast mechanotransduction for the treatment of fibrotic disorders. The Matrix Biology and Engineering and Systems Genetics Labs are integrating their unique mechanobiology, molecular and cell biology experimental expertise and established genomics and computational approaches to build novel therapeutic approaches to reversing tissue fibrosis. The Research Associate will perform research on the recently funded NIH Director's Transformative Research Award and work closely with both PIs and a team of quantitative molecular and cell biologists and computational biologists to create a new solution for a currently incurable disease.
The Research Associate will identify cell type-specific DNA regulatory elements and engineer sensor-actuator circuits for delivery into lungs and livers in various stages of fibrosis with the ultimate goal of dissolving fibrotic tissue. The discoveries will also lead to the understanding of temporal dynamics of how therapeutically targeting mechanical stimuli, such as tissue stiffness, alter the cell's signaling and phenotypic state.
Candidates must hold a PhD in Biomedical Engineering, Bioengineering, Quantitative Biology, Genetics/Genomics or a closely related field by the start date and lead-author publications in their fields. Candidates must also have strong communication skills and the ability to work both independently and as part of a large collaborative, transdisciplinary team. Prior experience in mechanotransduction, functional genomics, or transcriptional regulation is preferred.
To apply, visit https://jobs.virginia.edu and search on Posting Number 0621003. Complete a candidate profile online; attach a CV, cover letter, and contact information for three references. The position will remain open until filled. For a description of the labs' overall research interests, visit www.matrixbiology.net and http://civeleklab.org/. For questions about the position, please contact Dr. Tom Barker via email at firstname.lastname@example.org.
The University of Virginia is an equal opportunity and affirmative action employer and is committed to building a culturally diverse community and strongly encourages applications from underrepresented groups and dual career opportunities. Women, minorities, veterans, and persons with disabilities are encouraged to apply.
Founded by Thomas Jefferson, the University of Virginia opened in 1825 as the nation's first public university. A longstanding dedication to preeminence in both scholarship and teaching; top ranking in global satisfaction, collegiality and work/family issues on the COACHE survey of early career faculty; a commitment to excellence that is integrally connected with diversity and a broad array of ben...efits make the University of Virginia a prime choice for both faculty and staff. The University of Virginia is located in the small cosmopolitan city of Charlottesville near the Blue Ridge Mountains, 70 miles from Richmond and 110 miles from Washington, D.C. The University of Virginia remains the No. 2 best public university in the 2013 edition of the U.S. News and World Report rankings. In the 14 years since U.S. News began ranking public universities as a separate category, U.Va. has ranked either No. 1 or No. 2. U.Va. continues to rank in the Top 25 among the best of all national universities, public and private.