The candidate will work in the High-Throughput Screening Core (HTSC) in the Perelman School of Medicine (PSOM). He/she will work with the Scientific and Technical Directors of the core to further design, to optimize and validate biological assays in high-density formats (i.e. 384 well microtiter plates) for primary human cancers that can be screened against libraries of FDA approved drugs, as part of a collaborative research initiative between the Chemogenomic Discovery Program, Precision Medicine, and Hospital of University of Pennsylvania. The candidate will also dedicate effort to high-throughput cell based screens designed to dissect the role of epigenetics in cellular senescence. Specific responsibilities will include moderately complex procedures/techniques in eukaryotic/mammalian cell-culture, molecular biology, cell biology, and high-throughput genetic/chemical screening. The candidate will operate and maintain automated laboratory robotic workstations related to high-throughput screening; prepare and manage libraries of siRNA, shRNA, cDNA, CRISPR and drug-like small molecule libraries for high-throughput screening; and analyze, interpret, and prepare reports of large data sets. Additional responsibilities will include literature searches, maintaining articulate documentation of daily tasks and maintenance of the laboratory’s databases/logs and inventory (i.e. supplies, reagents, and equipment).
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class ...of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.