Minimum Qualifications: PhD in Biological Sciences or related field along with excellent organizational skills and proven ability to work independently required. Experience in cell culture, molecular biology, and/or ocular surgery on animal models (rabbits) is welcomed. The successful candidate will have excellent organizational and communication skills.
Job Standard / Operational Needs: Promoting regenerative healing in the eye. Scarring results from the persistence of myofibroblasts, cells that excessively contract tissue and secrete disorganized extracellular matrix. RNA sequencing of myofibroblasts revealed significant changes in the expression of genes coding for ubiquitin pathway components, including increased expression of a subset of deubiquitinating enzymes (DUBs). This project will 1) investigate the impact of the DUB, USP10 in regulating integrin-mediated scarring (signaling, cell differentiation, matrix contraction) and 2) test the efficacy of a self-delivery siRNA therapeutic to promote regenerative healing and prevent scarring in vivo.The project will use human primary patient-derived cells, organ culture, molecular and cell biological techniques as well as genetic and proteomic screening. The salary will be according to NIH guidelines, depending on the number of years of postdoctoral experience.
About State University of New York Upstate Medical University
SUNY Upstate Medical University in Syracuse, NY, is the only academic medical center in Central New York. It is also the region's largest employer with 9,460 employees. Affiliated with the State University of New York, Upstate's mission is to improve the health of the community through education, biomedical research and health care. Upstate Medical University's educational mission is anchored by i...ts four colleges?Medicine, Nursing, Health Professions and Graduate Studies (biomedical sciences). Since 2006, student enrollment has grown by 30% as Upstate responds to the needs of the region. As a biomedical research enterprise, Upstate focuses on the most prevalent human diseases, including cancer, diabetes, heart disease, nervous system disorders, vision, and infectious diseases. The quest for treatments and cures is built upon expertise in structural, molecular and systems biology. Upstate also offers many clinical trials for patients. The Upstate University Health System serves 1.8 million people, often the most seriously ill and injured, and includes Upstate University Hospital; Upstate University Hospital at Community Campus; Upstate Golisano Children's Hospital, and numerous satellite sites.