We are seeking an exceptional, highly motivated and team oriented full-time Research Scientist at 100% FTE, 2 year fixed term to join the Human Interactome Project, a collaborative research initiative at the newly-established Center for Receptor-Ligand Discovery in the Department of Molecular and Cellular Physiology at Stanford University School of Medicine. The successful candidate will work with a multidisciplinary and dynamic research team on a genome-wide project to study human cell surface protein interactions. The goal of HIP is to map all cell surface, receptor-ligand interactions in the human proteome. As interactions at the cell surface play a crucial and widespread role in regulating biological processes and disease states, de-orphanizing receptor-ligand interactions is essential for our understanding of cellular interactions in all biological systems and will provide therapeutic targets for drug discovery.
The position requires a highly self-motivated, accomplished individual with an outstanding track-record of innovation and success in both graduate school and postdoctoral research with a sustained publication record. The successful candidate will contribute to various R&D aspects of the Human Interactome Project that involve protein engineering and biochemistry, cell biology, molecular biology, structural biology, biophysics and bioinformatics. Specifically, the successful candidate will conceive, develop and optimize Luminex bead-based and other novel assays for screening receptor-ligand interactions that are amenable to high-throughput automation and, simultaneously, participate in further optimization and modification of existing receptor-ligand screening platforms. The methods utilized will encompass protein biochemistry techniques including protein purification, ELISA, SPR and Luminex bead technology; cell biological techniques including mammalian and insect cell culture, transfection, virus generation and infection, stable cell line development, immunostaining and FACS; molecular biology techniques including expression vector and library design and cloning, single cell extraction and sequencing; and the ability to develop bioinformatics tools for DNA and protein sequence analysis including programming and database development and management. Since it is unlikely that any candidate will possess all these skills, we are willing to consider any individual with a strong background in cell surface receptor-ligand interactions or development of high-throughput protein-protein interaction technologies who has experience with several of these techniques.
As the Human Interactome Project is being conducted both at Stanford and at off-site industry and academic institutions, the successful candidate will have a demonstrated history of success in establishing and performing collaborative research with excellent oral and written communication skills and the ability to take initiative, provide strategic input, problem solve and work in teams (both on- and off-site).
Stanford University is an equal opportunity employer and is committed to increasing the diversity of its faculty and academic staff. It welcomes nominations of and applications from women and members of minority groups, as well as others who would bring additional dimensions to the Universitys research, teaching, and clinical missions.
A Ph.D. or M.D. degree with at least 3 years of relevant postdoctoral research experience in academia and/or industry is required. A strong background in cell surface receptor-ligand biology, protein biochemistry, molecular biology, assay development and bioinformatics is highly desirable. Experience with high-throughput assay development and automated equipment including TECAN and other liquid handling instruments, Bio-Plex/Luminex systems, FACS systems, Octet system, ProteinSimple systems and Biacore 8K/Sierra MASS-2 systems is preferable. The successful candidate must be technically rigorous, possess exceptional organizational skills and attention to detail and have a track-record of excellence, innovation and productivity in research. Excellent interpersonal, communication and writing skills are imperative. The successful candidate must be able to work both independently and collaboratively and will have additional roles in the training of postdoctoral fellows, graduate students and staff members.
Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains d...edicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 9000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu.
Stanford University is an equal opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.