Summary Description: The Institute for Genomic Medicine at Columbia University Medical Center seeks a highly motivated and creative research scientist to participate in an NIH-funded study of brain somatic mutations in epilepsy. The successful candidate will develop and apply computational and statistical methodologies to identify and interpret the significance of mutations unique to tissue and cell populations in the epileptic brain from next-generation sequencing data from a large cohort of patients. Depending on the applicant's interests and skill sets, opportunities are also available to develop and refine of sequencing approaches to identify somatic mutations, to apply single-cell expression methodologies to study gene expression human epileptic brain tissue, to molecularly characterize disease-causing somatic mutations identified, and to study germline genetic variation in epilepsy and other neurodevelopmental disorders. The Institute for Genomic Medicine is a vibrant, highly collaborative research environment at forefront of precision medicine and therapeutic discovery. The Institute has a range of faculty with expertise in computational biology, statistical genetics, human and mouse genetics, pharmacology and neurosciences. We are particularly interested in individuals with bioinformatics, statistical, and disease genetics expertise. Excellent communication skills and fluency in both spoken and written English are essential.The successful candidate will be supervised by Dr. Erin Heinzen, Deputy director of the Institute for Genomic Medicine and Assistant Professor of Pathology and Cell Biology, and have significant interactions with faculty and other scientists in the Institute and at Columbia University.
Minimum Qualifications: Candidates should have or be very close to obtaining a Ph.D. in a relevant field.
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