We are seeking a motivated, scientifically curious and team-oriented person to join our studies into new treatments for cancer. This position is within the Laboratory of Professor Matthew Shair, Harvard University Department of Chemistry and Chemical Biology, and projects will include supporting preclinical advancement of drug candidates and exploring mechanism of action. This is a unique opportunity to engage with a multidisciplinary team of experts, including biologists, synthetic and medicinal chemists, pharmacologists, and clinicians, while gaining exposure to cutting edge drug discovery and development.
Job Description Plans, develops, designs and conducts complex research projects associated with the Shair laboratory's cancer biology effort. The position will combine genomic and proteomic studies with characterization of transcriptional regulatory pathways and phenotypic analysis to develop insights into mechanism of action. Techniques may include gene expression studies, proteomics/phosphoproteomics, flow cytometry, western blot, ChIP-seq, CRISPR/Cas9 screens, and molecular biology using cell lines and primary patient samples. The position will perform experiments, analyze and interpret results, and will present research findings. This position will coordinate and collaborate with other members of the research group and others outside the research group on a regular basis. The position will work independently and as part of the research team to contribute to the advancement of a new cancer treatment.
About the Shair Lab The Shair Lab at Harvard University is a preeminent lab conducting investigations at the interface of chemistry, biology and medicine. We use small molecules and cell biology as part of an integrated approach to study the mechanistic basis of human diseases, identify new druggable targets and develop therapeutics. Our research is highly interdisciplinary, with chemists and biologists working side-by-side. Chemists apply modern stereoselective synthesis to discover highly selective small molecules that target proteins involved in human disease. Biologists combine small molecules with genome-wide and proteome-wide studies, CRISPR-Cas9 genome editing and iPSCs and primary patient samples to investigate human disease. We invite you to learn more at www.shairlab.com.
All formal offers will be made by FAS Human Resources
Salary Grade: 057
Union: 00 - Non Union, Exempt or Temporary
Master's degree in molecular or cellular biology and five years of relevant research experience.
PhD in molecular or cellular biology with a background in cancer biology, especially hematologic malignancy, strongly preferred. Motivated self-starter with an enthusiasm for research; strong analytical and conceptual skills; comfortable in an academic environment; work well independently with attention to detail; and strong verbal and communication skills. Preference will be given to a candidate with cancer biology experience, especially in hematologic malignancy.
EQUAL OPPORTUNITY EMPLOYER: We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
About Harvard University Faculty of Arts and Sciences
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders in many disciplines who make a difference globally. The University, which is based in Cambridge and Boston, Massachusetts, has an enrollment of over 20,000 degree candidates, including undergraduate, graduate, and professional students. Harvard has more than 360,000 alumni around the world. T...he University has twelve degree-granting Schools in addition to the Radcliffe Institute for Advanced Study, offering a truly global education. Established in 1636, Harvard is the oldest institution of higher education in the United States.