We are seeking a highly motivated Postdoctoral Scholar to move our research forward. The Sherman Lab aims to understand the transcriptional and epigenetic gene-regulatory networks that underlie tumor-stroma interactions in pancreatic cancer, and to target these networks for therapeutic benefit. Our research focuses on the mechanisms by which stromal fibroblasts in the pancreatic tumor microenvironment influence cancer cell gene expression, metabolism, and growth. Our laboratory uses a multidisciplinary approach to investigate the mechanistic underpinnings of the pancreatic tumor microenvironment, including mouse models of pancreatic cancer, three-dimensional cell culture systems such as patient-derived organoids, and diverse molecular- and cell-biological techniques focused on gene regulation.
The ideal candidate for this position will be highly interactive, but capable of working independently on research focused on tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function, and how these stromal mechanisms affect cell fate and function in the pancreatic epithelium.
Ideal candidates should have no more than 1 year of postdoctoral experience, and are expected to compete for internal and external funding. Highly motivated candidates should upload a cover letter describing your relevant qualifications, future interests, and expected start date; CV; and names and contact information for three references.
Ph.D. or M.D./Ph.D., in related field of study
Excellent written and verbal communication skills.
Experience with model organisms, cell culture, functional analyses (proliferation/apoptosis assays, Western blot, real-time qPCR, etc.), and molecular cloning is required
First authorship on at least one paper in a peer-reviewed English language journal.
Experience in mouse models of cancer and high-throughput sequencing preferred.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and r...esearch. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm