The Curran laboratory in the Children’s Research Institute, Children’s Mercy Kansas City is seeking a highly motivated and enthusiastic postdoctoral research fellow to conduct high quality research in basic and translational science and to fulfill the Children’s Mercy mission of research excellence. Our laboratory will develop specific inhibitors of key cytosolic adaptor proteins in signal transduction pathways that control cell structure, motility, and growth. We will use the inhibitors to further elucidate biological functions of the adaptor proteins and to test the feasibility of the adaptor proteins as novel therapeutic targets for cancer and other human diseases. The postdoctoral research fellow will make a leading role in developing and characterizing chemical inhibitors of the adaptor proteins under the close supervision of a junior faculty member who is responsible for hiring and evaluation. First, the postdoc will develop a biochemical screening system. Second, the postdoc will collaborate with high throughput screening core facilities to discover specific inhibitors. Third, the postdoc will validate hit compounds using biochemical and cell-based assays to identify specific inhibitors. Fourth, the postdoc will study inhibitors’ structure-function relationship to improve affinity, specificity, and bioavailability. Then, the postdoc will use the inhibitors to characterize biological roles of the adaptor proteins in normal cells, tumor cell lines, and patient tumor tissues using in vitro cell culture and transplantation/spontaneous mouse models. The position is available immediately.
Qualified candidates must hold a Ph.D. degree or equivalent degree (preferably a recently received degree) in biochemistry, cell biology, molecular biology or a related field. Excellent oral and written communication skills and capabilities to work independently and on a team are necessary. Specifically, a candidate should have skills in molecular cloning, protein purification, cell culture, immunohistochemistry and immunofluorescence, and Western blot analysis. Candidates who have expertise in cancer, mouse genetics, and neuroscience are preferred.
Children’s Mercy Kansas City is an independent, non-profit 367-bed pediatric health system, providing more than half a million patient encounters yearly. In affiliation with the University of Missouri-Kansas City, the medical staff of more than 750 pediatric subspecialists and scientists is actively involved in clinical care, pediatric research, and educating the next generation of pediatric subsp...ecialists. Our physicians serve a medically diverse population from 150 counties, providing care to children with rare and complex disorders daily.
Our drive to find answers for these children and their families motivated us to create the Children’s Research Institute. The Children’s Research Institute is creating an integrated research environment where no boundaries exist between science and medicine. In our quest to find answers to pediatric medicine’s most challenging questions, we are collaborating with physicians, scientists, academic partners and others within our community, and around the world. To accomplish our goals, we’re performing the highest quality research using the latest medical technologies. The Children’s Research Institute is dedicated to conducting translational research—studies that translate medical research into better ways to diagnose and treat children with a wide range of medical conditions, from the common to the complex. The hospital’s leadership in pediatric genomic medicine and clinical pharmacology is driving research and innovation in nephrology, heart care, cancer treatment and other subspecialties to provide answers for the most difficult cases and challenging pediatric conditions. Our world-class scientists and physicians work together in a culture of collaboration and innovation because every child deserves our best, and every question deserves an answer.