School of Medicine Department of Microbiology and Molecular Genetics Position: Specialists, Open Ranks Junior, Assistant, Associate, and full Specialist positions are periodically available in the Department of Microbiology and Molecular Genetics at the University of California, Irvine. Requirements - Applications are being sought from BS, MS, or PhD degree candidates with strong laboratory research background and knowledge of wide set of molecular biology techniques. Salary is commensurate with experience. Faculty and their research interests: Alan G. Barbour, MD - Molecular pathogenesis and evolutionary biology of vector-borne infections. Emiliana Borrelli, PhD - The study of the dopaminergic system is approached through the generation and analysis of genetically engineered mice (knock-out mice) in which expression of dopamine receptors has been altered or abolished. The analysis of these mice at the molecular, biochemical and behavioral levels allows us to study the implication of dopamine receptors' signaling in the control of dopamine-regulated physiological functions which range from motor control to addiction to drugs of abuse. These studies are relevant to the understanding of human neurological and neuropsychiatric disorders. Alan L. Goldin, MD, PhD - Molecular and cell biology of sodium channels and diseases caused by sodium channel mutations. Klemens J. Hertel, PhD - Alternative splicing in biology and disease; quantitative and computational approaches to gain insights into the most critical steps of generating mRNA diversity, splice-site selection and pairing. Anthony A. James, PhD - Developing genetic techniques to control the transmission of vector-borne diseases, specifically malaria and dengue fever; investigating genome-wide patterns of gene expression in vector mosquitoes. Michael McClelland, PhD - Genetics and Genomics of Salmonella, with a particular emphasis on high-throughput methods, bioinformatics and statistics. The use of Salmonella as a delivery agent for cancer therapeutics. Prostate cancer diagnosis and prognosis. Rozanne M. Sandri-Goldin, PhD - Analyses of the mechanisms by which a herpes virus regulatory protein mediates inhibition of host cell splicing and facilitates the export of viral RNAs. Bert L. Semler, PhD - RNA virus gene expression; mechanisms of replication of picornavirus genomic RNAs; mechanisms of translation initiation for viral and cellular mRNAs. Yongsheng Shi, PhD - Mechanisms and regulation of mRNA processing, including splicing and polyadenylation, on a systems level; molecular basis of human diseases that are caused by aberrant mRNA processing. Ming Tan, MD - Molecular pathogenesis of Chlamydia (cause of sexually transmitted disease and linked with heart disease); transcriptional regulation of gene expression; studying global gene expression using DNA micro arrays. Marian L. Waterman, PhD - Role of LEF/TCF proteins in Wnt signaling and cancer expression, transcription activation and nuclear localization. APPLICATION PROCEDURE: Please send curriculum vitae, cover letter and names and address of three references to: https://recruit.ap.uci.edu/apply/JPF03928. "The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy."
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